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Dehydrogenase Definition
What Is Dehydrogenase?

Dehydrogenase is an enzyme that oxidizes a substrate by transferring one or more protons and a pair of electrons to an acceptor, usually NAD/NADP or a flavin coenzyme such as FAD or FMN. Examples for dehydrogenase are aldehyde dehydrogenase, acetaldehyde dehydrogenase, alcohol dehydrogenase, glutamate dehydrogenase (an enzyme that can convert glutamate to a-Ketoglutarate and vice versa), lactate dehydrogenase, pyruvate dehydrogenase (a common enzyme which feeds the TCA Cycle in converting Pyruvate to Acetyl CoA), glucose-6-phosphate dehydrogenase (involved in the pentose phosphate pathway), glyceraldehyde-3-phosphate dehydrogenase (involved in glycolysis), isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, malate dehydrogenase etc. The different dehydrogenase enzymes are classified according to the site of action. The dehydrogenase enzyme has a variety of action in different substrates. Dehydrogenase enzyme play a major role in Tricarboxylic acid cycle. Dehydrogenase Enzyme in the liver will not add any carbon at the 19th position.

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